Fig. 2. HIF target genes elevated during renal hypoxia (Rhabdo) or renal HIF activation (VHL-KO) are not changed following CsA treatment. Quantification (qPCR) of renal expression of selected HIF target genes: hexokinase-2 (Hk2), Glucose-1 transporter (Slc2a1 alias Glut1), adrenomedullin (Adm), heme oxygenase-1 (Hmox1), carbonic anhydrase-9 (Car9) and aldolase C (Aldoc) in different in vivo settings. CsA: daily CsA treatment of mice (60 mg/kg BW) for one week as described and shown in [11]. Rhabdo: Rhabdomyolysis induced AKI in mice as a model of renal hypoxia as described and shown in [21]. VHL-KO: transgenic mice with inducible, tubulus specific VHL-knock out served as model of renal HIF activation as described and shown in [21]. *: p<0.05, **: p<0.01, ***: p<0.001.